In the Spring of 1944, an informal discussion took place in Cambridge between Mr. R. S. Whipple, Professor Allan Ferguson and Mr. F. H. C. Butler, concerning the formation of a national Society for the History of Science. This is the opening sentence of the inaugural issue of the Bulletin of the British Society for the History of Science, the Society's first official publication. Butler himself was the author of this outline account of the subsequent approach to the Royal Society, (...) the parallel moves to establish a National Committee of the International Academy of the History of Science, the formation of a provisional committee to prepare a draft constitution for a national society, and the proceedings of the first Annual General Meeting in May 1947. Whipple had been in Cambridge to discuss his offer to present his collection of old scientific instruments to the University and the possible foundation of a new museum, and Butler, as Secretary of the History of Science Committee in Cambridge, was the chief mover in both this development and an initiative coupled with it to establish a department of the history of science. (shrink)

Amyloid-beta peptide plaque in the brain is the primary diagnostic criterion of Alzheimer's disease . The physiological role of Abeta are poorly understood. We have previously determined an Abeta interacting domain in the promoters of AD-associated genes . This AbetaID interacts in a DNA sequence-specific manner with Abeta. We now demonstrate novel Abeta activity as a possible transcription factor. Herein, we detected Abeta-chromatin interaction in cell culture by ChIP assay. We observed that human neuroblastoma cells treated with FITC conjugated Abeta1-40 (...) localized Abeta to the nucleus in the presence of H2O2-mediated oxidative stress. Furthermore, primary rat fetal cerebrocortical cultures were transfected with APP and BACE1 promoter-luciferase fusions, and rat PC12 cultures were transfected with polymorphic APP promoter-CAT fusion clones. Transfected cells were treated with different Abeta peptides and/or H2O2. Abeta treatment of cell cultures produced a DNA sequence-specific response in cells transfected with polymorphic APP clones. Our results suggest the Abeta peptide may regulate its own production through feedback on its precursor protein and BACE1, leading to amyloidogenesis in AD. (shrink)

The rule of double effect is regularly invoked in ethical discussions about palliative sedation, terminal extubation and other clinical acts that may be viewed as hastening death for imminently dying patients. Unfortunately, the literature tends to employ this useful principle in a fashion suggesting that it offers the final word on the moral acceptability of such medical procedures. In fact, the rule cannot be applied appropriately without invoking moral theories that are not explicit in the rule itself. Four tenets of (...) the rule each require their own ethical justification. A variety of moral theories are relevant to making judgements in a pluralistic society. Much of the rich moral conversation germane to the rule has been reflected in arguments about physician-asssisted suicide and voluntary active euthanasia, but the rule itself has limited relevance to these debates, and requires its own moral justifications when applied to other practices that might hasten death. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

The introduction of the trireme into Greek navies was an event of great political importance, which may fairly be compared to the introduction of the ‘all-big-gun’ battleship into the British Navy in 1907. Heavier, more powerful, and capable of carrying more πιβται, but making greater demands on timber supplies and manpower, the trireme not only rendered obsolete all existing Greek line-of-battle ships but gave a decisive advantage to those States whose resources in materials and men enabled them to create and (...) maintain adequate fleets of the new type of warship.1 It is a mark of the insufficiency of our sources for early Greek history that we nowhere find an explicit statement of the date at which this revolution occurred, or of the identity of the person responsible. (shrink)

There is as yet no settled consensus as to what makes a term a logical constant or even as to which terms should be recognized as having this status. This essay sets out and defends a rationale for identifying logical constants. I argue for a two-tiered approach to logical theory. First, a secure, core logical theory recognizes only a minimal set of constants needed for deductively systematizing scientific theories. Second, there are extended logical theories whose objectives are to systematize various (...) pre-theoretic, modal intuitions. The latter theories may recognize a variety of additional constants as needed in order to formalize a given set of intuitions. (shrink)

This essay examines the concept of "truth" from empiricist and pragmatist perspectives. This not without reference to other theories. The concern is to see how the ascendancy of pragmatism has affected humanity and may continue to affect humanity, the so-called objectivity in the practice of science and philosophy and the relationships between the diverse peoples of the world. An analysis of the pragmatist's preference for usefulness, rather than truth, it is argued, accounts for the deleterious consequences of pragmatism for humankind (...) in its almost irrational substitution of usefulness for truth. (shrink)

Most documented extinctions of vertebrates in the last 400 years have been island endemics. In this paper, we focus on the need to develop a historical framework to establish conservation priorities for insular faunas and, in particular, to test the validity of nominal endemics. We use the example of the islands of the North Pacific Coast of North America, a region that includes approximately one-half of all mammals endemic to North American islands north of Mexico. Few of these endemics have (...) been re-evaluated since their original descriptions, although many of these islands have been heavily impacted by habitat conversion, species introductions, over-exploitation, and secondary ripple effects. Evidence from molecular genetics and paleontology suggests that many taxa arrived in the region since the last glacial advance. Some of these nominal endemics show minimal differentiation, while others comprise multiple evolutionary lineages. The NPC may also have played an important role in the in situ diversification of some taxa during the Pleistocene. Evidence, such as new fossil discoveries and numerous described endemics, lends support for refugia hypotheses. However, these ideas cannot be tested until a better understanding of geographic variation and the evolutionary relationships of the fauna and flora of the North Pacific Coast is developed. This framework would provide significant insight into the dynamic biogeographic history of the region and help prioritize conservation efforts. (shrink)

It may be safely asserted that few of the fragments of Greek lyric poetry have excited more discussion than the so-called ‘Lament of Danae’ but it is curious, considering that we owe our knowledge of it to Dionysius's desire to set his readers a metrical puzzle, to see how little attention has been given to the metre of the fragment by the many scholars who have contributed to the literature of the problem since 1835. The purpose of the present study (...) is to enquire into the scansion of the fragment, quoting parallels wherever possible from the extant remains of Simonides and, where these fail, from the works of other lyric poets. (shrink)

The author deals with the meaning of metamerism. Two contrary points of view may serve to clear the problem. From the morphological point of view probably outgrowth of the organism in longitudinal direction has led to the development of metameres. So the first segmentation is due to a functional differentiation. In Phylogeny this segmentation has been maintained and the originally developed metameres remain the primary morphotic units of the organisms. Further specialising of function and organ-concentration destroyed the original absolute metamerism (...) and only left a rest of the original.The functional point of view renounces an original absolute metamerism for the present moment. It only asks for the functional meaning of the segmentation in organisms, showing this segmentation. From the functional point of view it is possible that metamerism may be the morphological expression of quite different functional requirements and that in one organism the metamerism starts from another system of organs than in another.Es wird gefragt welche Bedeutung die Metamerie haben kann. Zur Erläuterung des Problems werden zwei extremen Betrachtungsweisen einander gegenübergestellt. Nach der morphologischen Betrachtungsweise hat Wachstum der Organismen in die Länge wahrscheinlich zur Ausbildung der Metamerie geführt. Diese erste Metamerie ist wahrscheinlich ein funktioneller Differenzierungsprozess gewesen.In der Phylogenese hat sich diese Metamerie behauptet und die ursprünglich entstandene Metamere sind die primären morphotischen Einheiten der Organismen geblieben. Weitergehende Funktionsspezialisierung und Organkonzentration hat die ursprüngliche absolute Metamerie vernichtet. Was davon übrig blieb sind die Reste der ursprünglichen.Die funktioneile Betrachtungsweise verzichtet vorläufig auf eine ursprüngliche absolute Metamerie. Sie fragt bloss nach der funktionellen Bedeutung, welche die Metamerie besitzt bei denjenigen Organismen, wo diese gefunden wird. Sie achtet es möglich, dass Metamerie der Ausdruck sein kann von ganz verschiedenen funktionellen Anforderungen und dass somit die Metamerie bei der einen Tiergruppe von einem ganz anderen Organsystem ausgeht wei bei einer anderen. (shrink)

We would like to thank Dolega and Dewhurst for a thought-provoking and informed deconstruction of our article, which we take as applause from valued members of our audience. In brief, we fully concur with the theatre-free formulation offered by Dolega and Dewhurst and take the opportunity to explain why we used the Cartesian theatre metaphor. We do this by drawing an analogy between consciousness and evolution. This analogy is used to emphasize the circular causality inherent in the free energy principle. (...) We conclude with a comment on the special forms of active inference that may be associated with selfawareness and how they may be especially informed by dream states. (shrink)

We all ‘know’ that public opinion came to prominence in the political vocabulary of the late eighteenth century. It may be that this dates its rise a bit late, but it is not relevant to argue the matter here. My concern is rather that we be equally aware of the purposes for which people made use of the concept. Here I wish to consider various possible contexts for speaking or writing of public opinion, or ‘opinion’, as it was usually called (...) prior to the mid-eighteenth century. It may be possible to define, more fully than heretofore, the work that the expression did in eighteenth-century thought. As contemporary students of public opinion have been learning, an answer to this question may not even be wholly irrelevant to the task of specifying the nature of public opinion in our own time. (shrink)

This paper shows that, for a large range of parameters, the journal editor prefers to delegate the choice to review the manuscript to the biased referee. If the peer review process is informative and the review reports are costly for the reviewers, even biased referees with extreme scientific preferences may choose to become informed about the manuscript’s quality. On the contrary, if the review process is potentially informative but the reviewer reports are not costly for the referees, the biased reviewer (...) has no incentive to become informed about the manuscript. Furthermore, if the reports are costly for referees but the peer review processes are not potentially informative, the biased reviewers will never become informed. In this paper, we also present a web resource that helps editors to experiment with the review process as a device for information transmission. (shrink)

On p. 261 of MIND, No. 146 (April, 1928), the relation expressed by the words “is a itbfamily of” would be better expressed by some other phrase such as “is a subsystem of”. For the notion which I defined at the end of the note was, through a stupid mistake on my part, incorrectly described as “a family,” whereas really it should hare received some quite distinct designation such as “a maximal system”. The term “family” should of course be used (...) in the sense which the authors of Principia Mathematica.have assigned to it And this sense only coincides with the sense of “ maximal system ” in the special case where R is a one-one relation ; in other cases more than one family may be included in a single maximal system On it. 260 two small corrections are required. For “ Rbo ” read “ Rpo ”. And the footnote should have had the number “ 1 ” prefixed to it, making it clear that it is a footnote and refers to section (3), and is not a continuation of section (4). (shrink)

On p. 261 of MIND, No. 146 (April, 1928), the relation expressed by the words “is a itbfamily of” would be better expressed by some other phrase such as “is a subsystem of”. For the notion which I defined at the end of the note was, through a stupid mistake on my part, incorrectly described as “a family,” whereas really it should hare received some quite distinct designation such as “a maximal system”. The term “family” should of course be used (...) in the sense which the authors of Principia Mathematica.have assigned to it And this sense only coincides with the sense of “ maximal system ” in the special case where R is a one-one relation ; in other cases more than one family may be included in a single maximal system On it. 260 two small corrections are required. For “ Rbo ” read “ Rpo ”. And the footnote should have had the number “ 1 ” prefixed to it, making it clear that it is a footnote and refers to section (3), and is not a continuation of section (4). (shrink)

Condensed detachment is usually regarded as a notation, and defined by example. In this paper it is regarded as a rule of inference, and rigorously defined with the help of the Unification Theorem of J. A. Robinson. Historically, however, the invention of condensed detachment by C. A. Meredith preceded Robinson's studies of unification. It is argued that Meredith's ideas deserve recognition in the history of unification, and the possibility that Meredith was influenced, through ukasiewicz, by ideas of Tarski going back (...) at least to 1939, and possibly to 1930 or earlier, is discussed. It is proved that a term is derivable by substitution and ordinary detachment from given axioms if and only if it is a substitution instance of a term which is derivable from these axioms by condensed detachment, and it is shown how this theorem enables the ideas of ukasiewicz and Tarski mentioned above to be formalized and extended. Finally, it is shown how condensed detachment may be subsumed within the resolution principle of J. A. Robinson, and several computer studies of particular Hilbert-type propositional calculi using programs based on condensed detachment or on resolution are briefly discussed. (shrink)

Concern for the rapidly growing scale and intensity of the human exploitation of the environment, in particular the alienation of natural ecosystems, but also resource exhaustion, pollution, and congestion, leads one to wonder about the short time. horizons allowed for in decision making. Time preference is dictated by the rate of interest, allowing in practice a horizon often not exceeding several decades. I argue that this is unsatisfactory. Some minimal social rate of discount should not be enforced. Instead, it is (...) more feasible to set absolute environmental standards, thereby introducing quantity constraints on our decision making, within which time preference can be permitted to find its own level. This acknowledges that the myopia of human vision may not be a flaw but rather a biological design which has served us weIl in evolution. It may, therefore, be better to change the rules by introducing self-imposed collective constraints than to try to change the shortsightedness of people in their day-to-day grass-roots decision making. (shrink)

Concern for the rapidly growing scale and intensity of the human exploitation of the environment, in particular the alienation of natural ecosystems, but also resource exhaustion, pollution, and congestion, leads one to wonder about the short time. horizons allowed for in decision making. Time preference is dictated by the rate of interest, allowing in practice a horizon often not exceeding several decades. I argue that this is unsatisfactory. Some minimal social rate of discount should not be enforced. Instead, it is (...) more feasible to set absolute environmental standards, thereby introducing quantity constraints on our decision making, within which time preference can be permitted to find its own level. This acknowledges that the myopia of human vision may not be a flaw but rather a biological design which has served us weIl in evolution. It may, therefore, be better to change the rules by introducing self-imposed collective constraints than to try to change the shortsightedness of people in their day-to-day grass-roots decision making. (shrink)

Rorty saw the course of philosophy in the twentieth century as an effort to part from two major philosophical trends, namely historicism and naturalism, only to inevitably return at the end of a tortuous path to these very same tendencies. If we can concede without major objections Rorty’s diagnosis of the trends in contemporary continental and analytical philosophy, which seem to reveal the exhaustion of modern philosophy, based as it has been on epistemology, we must, on the other hand, examine (...) carefully the three main questions that this diagnosis leaves open: How does Rorty reconcile continental idealist subjectivism with materialistic behaviorism? Is it really inevitable that philosophy blinded by Geist are unable to question prevalent beliefs? Finally, is the acceptance of a liberalism that is not able to give reasons for itself the most effective and pragmatic liberalism? In answering these questions, it may not be possible to avoid a non-dogmatic, but pragmatic, metaphysics: a vocabulary of vocabularies that allows Rorty to speak of the problems of justice in Plato and Rawls, of the soul in Aristotle and Descartes, of the dystopias in Moro and Orwell. On pragmatic terms, perhaps a modest version of a metaphysic’s “vocabulary” turns out to be as legitimate and practical as any other vocabulary. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Pragmatism as Anti-Authoritarianism by Richard RortyJ. A. ColenRORTY, Richard. Pragmatism as Anti-Authoritarianism. Edited by Eduardo Mendieta. Cambridge, Mass.: The Belknap Press of Harvard University Press, 2021. xxxv + 236 pp. Cloth, $27.95This book reproduces Richard Rorty's manuscript of the Ferrater Mora Lectures held in Spain in 1996, about ten years before his death. The preface is signed "Bellagio, July 22, 1997." Robert Brandom's foreword for the book states (...) that its publication is an "epoch-making event" since it was "long-lost" in the abysses of Catalan and Spanish languages.We could think that this should be taken with a grain of salt, considering that large sections of the book were previously published even in English. Chapter 1, "Pragmatism and Religion," was printed in the Revue Internationale de Philosophie in 1999; chapter 2, "Pragmatism as Romantic Polytheism," was collected in The Revival of Pragmatism (ed. Morris Dickstein) in 1998; and lectures 3 and 4 appear in a 2000 book edited by Robert Brandom. Chapter 7 was printed in Rorty's Philosophy and Social Hope, and 8, 9, and 10 were published in his Philosophical Papers.So truly, only chapters 5 and 6 were entirely ignored by the Anglophone reader. Rhetoric aside, it is nonetheless a very important book, and perhaps even an epoch-making one, although the Rortian scholar will never find himself in unchartered territory. It is indeed epoch-making for at least three different kinds of reasons.Firstly, the complete book with Rorty's own preface and all the lectures set together, carefully edited by Eduardo Mendieta, with notes and an insightful epilogue, presents Rorty's "mature version and vision of his path-breaking pragmatism." The oral nature of the delivery adds some charm to the text, and the recovery of the whole book-length text is epochal since, in spite of being a prolific writer of distinctive and provocative texts, Rorty's books are scarce: He wrote just four important books, in comparison with hundreds of shorter pieces. (It could even be argued that even his four main books are "fragments" that in some instances lack cogency.)Secondly, the political landscape has largely changed. People used to fight for the Truth. It may very well be that the combat of ideas by resorting to words with capital letters, interesting as it often is, doesn't make for the best arguments. When the flag of Truth (uppercase) is raised in politics, reason easily becomes the prey of the passions of the soul. Mendieta aptly titled his interviews with Rorty with the motto "take care of freedom and Truth will take care of itself." The notion that the highest [End Page 363] degree of freedom and tolerance and the lowest degree of dogmatism arise when no truth is believed was not Rorty's own invention, and in fact it has a long ancestry. But Rorty is surely among its most vocal advocates and a remarkable thinker. Right now, the situation looks entirely different. Rorty's indefatigable struggle against the idea of truth in politics was all too successful. Could it happen that the owl of Minerva rises again at dusk, and the book emerges when people are no longer fighting about truth but against fake news? In fact, a new post-truth era was just inaugurated. Thus, the book makes an amazing read for those who are interested in the genealogy of an old idea: the death of Truth—an irony that Rorty would have appreciated.Thirdly, Rorty is an unavoidable figure in contemporary political philosophy, but his pragmatism has always been somewhat mysterious. Despite his praise of the early pragmatists and his dismissive attitude towards "depth," very few doubt that his arguments are deeper and go further than, say, John Dewey's. Nor was he exactly one of the so-called new pragmatists such as Putnam, Huw Price, or Robert Brandom. Nevertheless, his bold and iconoclastic attacks on "representationalism," the naïve idea that language and thought merely mirror the world, really were influential, or even gave birth to a new pragmatism. But he was not one of them. (Etienne Gilson used to quote a saying according to which God... (shrink)

Peter Elmsley once said ‘difficillimum opus esse accuratam librorum collationem’. He was pointing out some mistakes in Porson's collation of the editio princeps of the four plays of Euripides, which Porson had said that he himself had collated ‘summa cum religione, ne dicam superstitione’. These were both men who knew Greek and who could collate manuscripts. So we ν;θρωπσκοι who would follow in their footsteps in this most difficult task cannot expect to do more than increase in some small measure (...) the accuracy and completeness of existing collations. It is to be hoped that others in their turn may in due course improve on our work also, so that finally, with sufficient workers in the field, a close approximation to truth may be achieved. (shrink)

Observations with respect to the relationship between symptoms and diseases can seriously be biased by selection phenomena. This selection may occur from the general population, via consultation behavior, diagnostic and therapeutic activities of the general practitioner, and by referral.Relationships may be suggested and reproduced even if they do not exist in unselected populations, as a product of diagnostic routines. Correction for selection bias can only be achieved by choosing proper comparison groups. While this can be done in a general practice (...) setting, this is almost impossible after referral, as is demonstrated in this paper. Surprisingly, the most unbiased estimation of the relationship between symptoms and diseases after referral can be made from patient groups that are referred for reason unrelated to the disease under study. (shrink)

In our target article, we presented the idea that involuntary autobiographical memories (IAMs) and déjà vu may both be based on the same retrieval processes. Our core claim was thus straightforward: Both can be described as “involuntary” or spontaneous cognitions, where IAMs deliver content and déjà vu delivers only the feeling of retrieval. Our proposal resulted in 27 commentaries covering a broad range of perspectives and approaches. The majority of them have not only amplified our key arguments but also pushed (...) our ideas further by offering extensions, refinements, discussing possible implications and providing additional empirical, neuroscientific and clinical support. The discussion launched by the commentaries proves to us the importance of bringing IAMs and déjà vu into mainstream discussions of memory retrieval processes. (shrink)

This is partly a verbal question, depending on the meaning of the word ‘caste’. I propose to assume that if we say that a State is a caste State we imply at least two things: that its members are divided into mutually exclusive endogamous classes, and that no one may be transferred from one class to another—unless possibly to a lower class. The State which Plato describes in the Republic satisfies the first of these conditions. Dr. Popper, who believes that (...) it is a caste State, maintains that it also satisfies the second. In addition he contends that the original basis of the class division is racial. My object in the notes which follow is to argue that both these contentions are false. (shrink)

Isaac Newton's closest approach to a system of the world in the critical period 1681–84 is provided in a set of untitled propositions concerning comets. They drastically revise his position maintained against Flamsteed in 1681 and may signal his adoption of a single comet solution for the appearances of 1680/1. Points of agreement and difference with the key pre-Principia texts of 1684–85 are analysed. He shows substantial control of the phenomena of tails which change very little in mechanical detail throughout (...) his subsequent work. An emerging theory of gravitation brings planets, their satellites, and comets under the same laws of motion, yet retains a celestial vortex and includes a singular proposition in lieu of the usual formulation of Keplers area law. The analysis raises questions on a number of issues of recent Newtonian scholarship ranging from his achievement following his correspondence with Robert Hooke in 1679 to his veneration of the wisdom of the ancients. (shrink)

Chapter 47 contains a sentence which has been the subject of a good deal of controversy and is manifestly corrupt. In the codex it reads as follows: κα τοᾁτων πνω μαιμᾃτατον θνος Bακτριανν π βασιλα οσαν διον τπον κα 'Aλξανδρος ρμηθες π τν μερν τοᾁτων ρι τοȗ Γγγον διλθε κτλ. Attempts have been made to connect this sentence with the rulers of the Kushan dynasty. It has even been suggested that οσαν represents Kονσαν : the suggestion naturally won no acceptance, (...) but one may point out that in any case it failed to attack the real difficulty, which lies in the words διον τπον On that essential point, the views of recent editors have both varied and combined. (shrink)

In a previous article an elementary semantic analysis showed that, logically, analogical terms and expressions must be treated as homonyms, though of a special type. The latter qualification is necessitated by the concomitant element of similarity that is found to be involved in all comparisons of the analogical type. Further, it was pointed out that the special types of similarity in question cannot be isolated through a purely semantic analysis. This is, in particular, a consequence of the fact that analogy (...) is itself an analogical notion and term. The kind of similarity involved may, therefore, vary in the different forms of analogy and it may prove impossible to abstract from these something like a common element, e.g., a particular type of resemblance. This implies that the full philosophical significance of a particular form of analogy can be gleaned only from a contextual examination of its rôle in relation to a particular problem. Nevertheless, some significant conclusions may emerge from a partial analysis of certain forms of resemblance which are usually associated with analogy. (shrink)

When we from what may be called Aristotle's Cosmology turn to his work traditionally called the Metaphysics, we are faced with something—an inquiry or doctrine—of a surprisingly different character. There what we find is the exposition of a sort or degree of knowledge superior to that of the Sciences. This is what we call his metaphysics, but he does not so name it; he names it Wisdom, or Theoretical Wisdom. At times he calls it First Philosophy, or, again, Theology. It (...) is par excellence knowledge, the consummate achievement of theoretic or cognitive power. It is the supreme Science, scientia scientiarum. Of what is it knowledge? It is knowledge not about, but of, whatsoever is real, really real, and of its universal and necessary attributes. The latter are distinct from one another, and from that to which they indissolubly belong, and metaphysics apprehends all this in its distinctions and interconnections. Further, it is a knowledge of itself, a knowledge of knowledge, and so a Wissenschaftslehre, or“super-Logic.” Finally, it is knowledge commensurate with the real Universe as a whole, so that nothing which is genuinely a part of that escapes its view. (shrink)

I. Eth. Nic. III. c. I, § 16. In spite of what Bernays and others have done to clear up this chapter, many perplexities remain. To some of these I propose later to return, but here I confine myself to one. Among the possible circumstances of an act, ignorance of which is excusable and may excuse, is enumerated τò ο νεκα. Nothing but desperation could have led the commentators to suggest that here τò ο νεκα means the actual effect or (...) result of the act . It may be sufficient to quote the notes ad loc. of these two scholars: 1. Stewart: ‘The o νεκα here is not, as usual, the intention of the doer, for he cannot be ignorant of what he intends to do; but the outcome or result of what he actually does, which is the opposite of the intention.’. (shrink)

The historic task of Leibniz was to furnish a philosophy of personality, and at the same time, and in harmony with it, a general interpretation of the physical world. He conceives therefore of a plurality of Real Beings which in their most developed form he proposes to call individuals, defining individuality in terms of unique experience. Further, he finds the monads, or so-called metaphysical points, to be centres of life, held together by their own inner or intensive force and therefore (...) impenetrable. Consequently, when we enquire whether the Real Beings are parts of the universe, we find that since the universe is the aggregate of monadic forces, all Real Being is finite, and so in order to deal with the problem of Theism we have to reconcile the concept of divine personality with what we may define as personality in the case of human beings. (shrink)

In this much-vexed passage a form or variant of ναγνρισς is described and exemplified. It is said to be συνθετ, which word all the translations I have seen render ‘compound’ or ‘composite,’ but their authors either omit or clearly fail to explain in what sense this form is said to be ‘composite.’ I believe that this translation is wrong, and that the word here means something else, συνθετος λόγος is good Greek for ‘a made-up tale’ . The point is not (...) that what is said or told is necessarily a lie, but that it is untrue, baseless, not founded on fact. All this is supported by the use of the corresponding verb in e.g. Thuc. I. cc. XXI. and XCVII., where it is opposed to the truthful recording of facts . Further, it justifies Dacier's reading in 1459a 21, where the relative clause refers to στοραις not to τς συνθσεις. The characteristic of a poetic σνθεσις is that it is a connected narrative which has a causal nexus between its parts, and so is of μα πρξις, whereas an στορα is a record of disconnected happenings to a single person or group of persons during a certain period. Such a σνθις may be merely made-up or fictional. It is specially so where it has no basis in fact , but is the sheer invention of the poet. Clearly such a fiction must be rendered acceptable or plausible, and this can only be done through someone being misled, and this misleading implies that that someone draws a wrong conclusion from evidence present or presented to him— i.e. it presupposes a παραλογισμός. (shrink)

In this much-vexed passage a form or variant of ναγνρισς is described and exemplified. It is said to be συνθετ, which word all the translations I have seen render ‘compound’ or ‘composite,’ but their authors either omit or clearly fail to explain in what sense this form is said to be ‘composite.’ I believe that this translation is wrong, and that the word here means something else, συνθετος λόγος is good Greek for ‘a made-up tale’. The point is not that (...) what is said or told is necessarily a lie, but that it is untrue, baseless, not founded on fact. All this is supported by the use of the corresponding verb in e.g. Thuc. I. cc. XXI. and XCVII., where it is opposed to the truthful recording of facts. Further, it justifies Dacier's reading in 1459a 21, where the relative clause refers to στοραις not to τς συνθσεις. The characteristic of a poetic σνθεσις is that it is a connected narrative which has a causal nexus between its parts, and so is of μα πρξις, whereas an στορα is a record of disconnected happenings to a single person or group of persons during a certain period. Such a σνθις may be merely made-up or fictional. It is specially so where it has no basis in fact, but is the sheer invention of the poet. Clearly such a fiction must be rendered acceptable or plausible, and this can only be done through someone being misled, and this misleading implies that that someone draws a wrong conclusion from evidence present or presented to him— i.e. it presupposes a παραλογισμός. (shrink)

κάτοπτρον, which is in all the manuscripts, was emended by Canter to κάτοπτον, and this emendation, or Headlam's κατόπτην, has been received by subsequent editors. Those who read κάτοπτον have been in the habit of taking the word to mean here ‘looking down upon’, and in support of this interpretation they sometimes adduce a scholium in M, κατόψιον. This does seem to prove that the scholar, whose note is copied in our scholium, found κάτοπτον in his text. Presumably he took (...) Σαρωνικο πορθμο κάτοπτον to signify ‘descried from the Saronic gulf’, having very possibly in his mind the phrase in Euripides, Hippolytus 30, where the temple of Cypris is said to be κατόψιον γς τσδε, visible from Troezen. At least we ought not without proof to lay to his account what appears to be the solecism of regarding κάτοπτον as if it meant ‘looking down upon’. Headlam's κατόπτην has at least an active force, but I cannot find that it means ‘one who looks down upon’, if that is the sense desired; it is a ‘spy’ or an ‘inspector’. And, at the end of all discussion, when one asks what in fact is this peak or headland that ‘looks down upon the Saronic crossing’, then commentators take refuge in silence or tend to contradict one another. An emendation that nobody can be sure he understands can hardly be regarded as satisfactory. It may be feared that what has happened is this. In order to get rid of κάτοπτρον, which appeared to them devoid of meaning, editors have introduced into the text a word which does not mean what they want it to mean, and which, if it had that meaning, would still present us with a picture which no man can recognize. (shrink)

The traditional text of Thucydides, II. 1, dates the surprise of Plataea by the Thebans, which began the Peloponnesian war, έπì ΠυΘοδώρου τι δύο μνας ρχοντος Αθηναίοις. It has long been recognized that the two months are too short a time, and that the facts of the history demand four. The day cannot be precisely determined, but the narrative of Thucydides fixes it near the end of a lunar month, and the choice has lain between the new moons of March (...) 8 and April 7, 431 B.C. Now that Meritt has shown that the year of Pythodorus was not intercalary and ended on July 2, the former must be accepted. Accordingly the Theban attack may be put on the night of, let us say, March 3, which by Attic reckoning would be the early hours of Anthesterion 27. (shrink)

The Australian HREC system is now highly centralised and subject to national guidelines in an attempt to assure consistency of decision-making and of ethical standards. The penalty has been greatly increased paperwork and reporting requirements which many committees feel burdensome. In addition, many Committees may be under-resourced. However, I argue that though it is timely to reassess the current directions it is an exaggeration to claim that the system is in danger of collapse.

In the first part of this paper we indicate how Meredith's condensed detachment may be used to give a new proof of Belnap's theorem that if every axiom x of a calculus S has the two-property that every variable which occurs in x occurs exactly twice in x, then every theorem of S is a substitution instance of a theorem of S which has the two-property. In the remainder of the paper we discuss the use of mechanical theorem-provers, based either (...) on condensed detachment or on the resolution rule of J. A. Robinson, to investigate various calculi whose axioms all have the two-property. Particular attention is given to D-groupoids, i.e. sets of formulae which are closed under condensed detachment. (shrink)

The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated loci (...) in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

By now widely read, Catherine Wilson’s book on Leibniz’s metaphysics needs no introduction to Leibniz scholars. This volume, like its companions in the ‘Studies in Intellectual History and the History of Philosophy’ series, succeeds in meeting high standards of historical and textual scholarship; of special note are Wilson’s remarkable grasp of the contribution that relatively minor figures made to Leibniz’s thought, and her familiarity with the European secondary literature. The book is, as a consequence, broader and historically richer than other (...) books on Leibniz in English. Contributing to this historical flavor is also a more strategic feature of Wilson’s project—namely its exploration of Leibniz’s metaphysics “[not] as a collection of theses and principles, but developmentally and thematically”. The distinction seems to imply that while one could view Leibniz’s metaphysics as a collection of principles and theses, exactly “which principles and theses?” threatens to get wrongly answered: the “governing assumption” of a developmental approach is that “what the words of a [long-dead philosopher] mean cannot be determined by an internal inspection of the texts”. Or anyway, not precisely determined, with a high confidence of Leibniz’s intentions, and for some projects this may well matter. Surely it may well matter for someone inclined—as Wilson is not—to see the largest part of Leibniz’s metaphysics as a relatively unified system of theses and principles: the governing assumption, which beckons us to read Leibniz against the backdrop of his ancient, medieval, and modern heritage, is consistent with exploring the internal coherence of the theses and principles making up his metaphysical system. If much of the older secondary literature was mistaken in doing almost to the exclusion of, Wilson’s book can scarcely be charged with the same mistake. Were I asked to complain about Wilson’s approach, I would only suggest that her eagerness and ability to do has sometimes obscured the extent to which an internal inspection of the texts is needed in fairly doing. (shrink)

Any theory of information needs to comply with what we call the implementation, formalization, and representation constraints. These constraints are justified by basic considerations concerning scientific modelling and methodology. In the first part of this paper, we argue that the implementation and formalization constraints cannot be satisfied because the relation between Shannon information and IIT must be clarified. In the second part of the paper, we focus on the representation constraint. We argue that IIT cannot succeed in satisfying this constraint (...) for semantic contents without offering models for concepts, conceptual roles, and context sensitivity. In the final part of the paper, further complications are raised with respect to the distinction between consciousness and attention, which apply more specifically to the representation constraint. We conclude with some recommendations as to how IIT may succeed in solving these problems, highlighting the advantages and enormous potential of IIT as a scientific theory. (shrink)

Since the Reformation and Enlightenment, the Western world has witnessed the incremental decline of religious influence. Yet, key legal protections and duties incumbent on civilians and state actors in both avowedly secular states and ruling theocracies, predominantly Islamic, are to a lesser or greater extent determined by religious values. Although it is often claimed that the modern secular state encourages the adoption of liberal values and allows for the formulation of general law according to the free will of its people, (...) the historical legacy of law and particularly its synthesis with the Judeo-Christian heritage is apparent. In the UK, the continuing centrality of religion in what purports to be a secular system of laws, is demonstrated by the introduction of elements of Sharia law. In an increasingly culturally-diverse society, the recognition of Islamic law may be interpreted as the tacit acknowledgement of the existing inherent faith influences which continue to inform many legal innovations, and represents an explicit attempt to rebalance the privileging of one set of precepts above another. It is suggested that religion continues to occupy a central position in lawmaking; performing a cultural, political, institutional and, importantly, symbolic role and this is evidenced for instance by the narratives which are imposed on individuals in relation to areas of topical significance such as matrimony, terminal illness, abortion, gender and sexual morality. This paper argues against those pronouncements of the retreat of religion in state affairs and, rather, reveals a set of key structural relations and signifiers which are informed by opinions redolent of, not least of all, a peculiar generic proscriptive religiosity. (shrink)

An attempt to set forth a single principle, i.e., truth, as a standard of value in terms of which all problems may be dealt with. The book provides an excellent negative illustration of the value of a thorough grasp of traditional philosophy. --J. A. B.

Moral strangerhood is due in part to competing worldviews. The profession of nursing is experiencing a paradigm shift which creates ethical dilemmas for both Christian nurses and Christian patients. Nursing's new focus on spirituality and spiritual care presents itself as broadly defining a desired state or patient outcome — spiritual integrity — supposed to be applicable to all patients of all faiths. Analysis of nursing's definition of spirituality reveals assumptions and values consistent with an Eastern/New Age worldview which may cause (...) hostility towards Christian patients stereotyped as dogmatic or noncompliant. (shrink)

When we are most immersed in literary reading, and when that immersion is most significant, we may experience a literary work as constitutive of a ‘world’. With reference to the phenomenological tradition, it can be shown how this world is both a novel creation and serves to disclose, not least by shifting our perspective from, the world of ordinary experience. In this light, it will be shown how the problem of mimesis poses a challenge for recent neuroscientific approaches to literature. (...) At the same time, neuroscientific findings show the insufficiency of phenomenological accounts which fail to acknowledge the physiological and cognitive processes that underlie literary imagining. I introduce the notion of the ‘mimetic dimension’ in order to clarify what accounts based on phenomenology and neuroscience can and cannot explain about literary mimesis and the experience of a literary world. (shrink)